Inflammatory Bowel Disease WHAT IS INFLAMMATORY BOWEL DISEASE? Inflammatory bowel disease refers to the condition that results when cells involved in inflammation and immune response are called into the lining of the GI tract. This infiltration thickens the bowel lining and interferes with absorption and motility (the ability of the bowel to contract and move food). With abnormal ability to contract and abnormal ability to absorb, the bowel’s function is disrupted. Chronic vomiting results if the infiltration is in the stomach or higher areas of the small intestine. A watery diarrhea with weight loss results if the infiltration is in the lower small intestine. A mucous diarrhea with fresh blood (colitis)  results if the infiltration occurs in the large intestine. Of course, the entire tract from top to bottom may be involved. Many people confuse Inflammatory Bowel Disease with “Irritable Bowel Syndrome,” a stress-related diarrhea problem. Treatment for “IBS” is aimed at stress; it is a completely different condition from “IBD.” WHY WOULD THE VET THINK MY PET MIGHT HAVE INFLAMMATORY BOWEL DISEASE? A little vomiting or diarrhea here and there seems to be pretty standard for pet dogs and cats. After all, cats groom themselves and get hairballs. Dogs eat all sorts of ridiculous things they aren’t supposed to.  Still, many owners notice that their pets seem to have vomiting or diarrhea a bit more often than it seems they should. It might be subtle where one notices that one is cleaning up a hairball or vomit pile rather more frequently than with previous pets or it could be the realization that one hasn’t seen the pet have a normal stool in weeks or months. Typically, the animal doesn’t seem obviously sick. Maybe there has been weight loss over time but nothing acute. There is simply a chronic problem with vomiting, diarrhea or both. Inflammatory bowel disease is probably the most common cause of chronic intestinal clinical signs and would be the likely condition to pursue first. HOW IS INFLAMMATORY BOWEL DISEASE DIAGNOSED? The first step in pursuing any chronic problem is a “metabolic database.” This means a basic blood panel and urinalysis to rule out more biochemically widespread problems (such as liver disease or kidney disease) which could be responsible for the signs.  Since inflammatory bowel disease is localized to the GI tract, such a database is usually normal (but might express a general inflammatory response in the blood or a loss of blood proteins as often there is a “leaking” of albumin (an important blood protein) from the intestine into the bowel contents). Radiographs may also be a good idea to rule out growths in the abdomen or tumors which could be accounting for the chronic problems. A trial of a simple medication such as metaclopramide (Reglan) or metronidazole (Flagyl) is often performed to see if there is symptomatic relief. If this kind of non-invasive testing is not revealing then the definitive test for inflammatory bowel disease is needed: a biopsy. Tissue samples must be harvested from several areas of the GI tract. This can be done either surgically or via endoscopy. Endoscopy involves the use of a skinny tubular instrument (an endoscope) which has a tiny fiber optic or video camera at the end. The endoscope is inserted down the throat, into the stomach and into the small intestine and small pinches of tissue are obtained via tiny biting forceps. If the large intestine is to be viewed, a series of enemas is needed prior to the procedure as well as a relatively long fast. The endoscope is inserted rectally and again tissue samples are harvested.  The advantage of this procedure over surgery is that it is not as invasive as surgery. Patients typically go home the same day. Disadvantages are expense (often referral to a specialist is necessary) and the fact that the rest of the abdomen cannot be viewed. Growths that are seen via endoscopy cannot be removed at that time and a second procedure typically must be planned whereas, if surgical exploration is used to obtain the biopsy, any growths can also be excised at that time. Surgical exploration may also be used to obtain samples. The recovery afterwards is typically a couple of days though some patients bounce back immediately. With surgery, other organs can also be sampled and abnormal sections of tissue can be removed. Surgery tends to be more expensive than endoscopy but this depends on the recovery period. Often these two procedures work out to be of similar expense. Tissue samples obtained are processed by a special laboratory and analyzed. The infiltration of inflammatory cells is graded as mild, moderate, or severe and the type of cells involved in the inflammation are identified. WHAT CAUSES INFLAMMATORY BOWEL DISEASE? Unfortunately, the causes of inflammatory bowel disease are not well understood. Usually, a cause is not found. The basic theory is that “something” is leading to a chronic stimulus of inflammation.  This could be an allergy against a food protein, the continuing presence of a parasite, inflammatory products produced by the normal bacteria living in the intestine or there may be an underlying problem with the immune system in affected individuals. Obviously, there may be different causes in different individuals or a combination of the possibilities listed working together. Most of the time an extensive search for the underlying cause is not made. WHAT ARE OTHER CAUSES OF CHRONIC VOMITING OR DIARRHEA? It is important to rule out parasitism as best as possible in cases such as these. A fecal flotation for worms is a good idea. Parasites such as whipworms or giardia may be difficult to detect so a short course of treatment to rule out their presence might also be a good idea, especially in the dog. Pancreatic Enyzyme insufficiency or chronic pancreatic inflammation might cause chronic vomiting or diarrhea. A special blood test called a “Trypsin-like immunoreactivity” test is required to rule out these possibilities. Pancreatic Enzyme Insufficiency is an especially important problem in German Shepherd dogs. More serious causes of chronic gastrointestinal complaints might include intestinal cancer (especially lymphosarcoma/lymphoma), fungal infection infiltrating the GI lining, or a lymphatic condition called “lymphangiectasia.” A biopsy will differentiate inflammatory bowel disease from these other conditions. An infection in the stomach with a special bacterium called Helicobacter is associated with inflammatory bowel disease, but we do not know enough to establish which is the “cause” and which is the “effect.” Helicobacter infection can lead to ulceration and inflammation, compounding the problems of the inflammatory bowel disease. HOW IS INFLAMMATORY BOWEL DISEASE TREATED? The cornerstone of treatment for inflammatory bowel disease is suppression of the inflammation. In milder cases of large intestinal inflammatory bowel disease, the immunomodulating properties of metronidazole (Flagyl) might be adequate for control but usually prednisone is needed. Prednisone will work on inflammatory bowel disease in any area of the intestinal tract. In more severe cases, stronger immune suppression is needed (as with cyclosporine or azathioprine). Higher doses are usually used in treatment at first and tapered down after control of symptoms has been gained. Some animals are able to eventually discontinue treatment or only require treatment during flare-ups. Others require some medication at all times. Long term use of prednisone should be accompanied by appropriate periodic monitoring tests due to the immune suppressive nature of this treatment. Dietary manipulation may also be helpful in the management of inflammatory bowel disease depending on the patient’s interest in newer foods.\ HOW CAN DIET BE USED TO TREAT INFLAMMATORY BOWEL DISEASE? The first step in dietary management of inflammatory bowel disease is fat restriction. Fat prolongs the time food spends in the stomach which tends to promote nausea.  There can also be undesirable interactions with fats and the bacteria of the intestine. The second step in using diet as therapy for this condition is to use a protein source with which the patient is inexperienced. Such a novel diet is considered “hypoallergenic” and removes any immunological stimulation by dietary properties. While there is no “hypoallergenic diet” that is appropriate for all patients, many food companies have recognized the need for diets such as these and something may be specially ordered. Such diets are typically based on duck, venison, or rabbit proteins. For more information on hypoallergenic diets, see our Food Allergy Page. This includes information on where to obtain such diets. Some specialists have recommended the use of what is called a “sacrificial” protein. This kind of treatment involves using one novel protein during initial treatment stages while the intestine is still inflamed and switching to another one when signs have been controlled. The theory is that an allergy to the initial protein is more likely to develop while the intestine is still diseased. Another approach is to use a diet  that uses “hydrolyzed” or pre-digested proteins. These proteins are too small to excite the immune system and are also especially easy for the inflammed intestinal tract to absorb. Hills Z/d diet and Purina’s CNM-HA are examples of this type of food. Insoluble fibers have been helpful in inflammatory bowel disease. They increase fecal bulk which stimulates more normal motility from the intestine. Slower stool passage results which enhances water absorption. Adding oat bran to the hypoallergenic diet may be helpful. IS IT AT ALL REASONABLE TO JUST TRY TREATMENT AND SKIP THE EXPENSIVE DIAGNOSTICS? Possibly. The problem with the prednisone trial involves the possibility of intestinal lymphosarcoma (also called lymphoma). This is a type of cancer that produces chronic diarrhea or vomiting just as inflammatory bowel disease can. Lymphoma is temporarily responsive to prednisone but the response is short-lived. Exposure to prednisone will make the lymphoma much more difficult to diagnose should biopsies be obtained later. Plus exposure to prednisone can lead to resistance to other medications. (This is less of a problem for cats, but in the dog even a few days of prednisone can make a lasting remission impossible to achieve.) In short, if one tries prednisone without confirming a diagnose, one an cause some harm should a lymphoma be present instead.